Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis
2005
The development of specific
targeted therapies, such as anti-TNF-α treatment, for chronic
inflammatory disorderssuch as rheumatoid arthritis, has significantly improved treatment, although not all patients respond. Targeting cellular adhesion molecules and chemokines/
chemokine receptorsas regulators of the
extravasationand migration of leukocytes may provide a novel approach for the treatment of these diseases. Moreover, the possibility of developing small-molecule antagonists offers an excellent method for the oral delivery of compounds with a short half-life.
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