Current status of radiant whole-body hyperthermia at temperatures > >41.5 C and practical guidelines for the treatment of adults. The German 'Interdisciplinary Working Group on Hyperthermia'

The term ‘extreme’ whole-body hyperthermia (WBH) describes the procedure of raising a patients’ body-core temperature to 41.5–42.0°C for 60 min. WBH represents the only hyperthermia technique that enables systemic heat treatment in patients with disseminated malignancies and is, therefore, usually combined with systemic chemotherapy. Up to now, several WBH-approaches have proved to be safe and associated with acceptable toxicity rates when radiant heat devices are employed. Until the late 1990s, the use of radiant WBH was restricted to a few specialized treatment centres worldwide. During the last 5 years, a larger number of WBH-devices were put into operation particularly in Germany. As a result, a novel generation on phase II trials on chemotherapy and adjunctive WBH in patients with various malignancies has been completed. Based on the promising results observed herein, first multi-centric phase III-trials on chemotherapy ± WBH have been initiated, with a considerable number of patients treated at Germ...