Field Cancerization: Treatment.

Abstract The goal of field cancerization treatment is to reduce the risk of developing keratinocyte carcinoma. Selecting the appropriate therapy depends on the degree of field cancerization and number of invasive cutaneous squamous cell carcinomas.1,2 Other considerations include treatment efficacy, cost, side effects, and patient preference. Field therapies are preferred as they address clinically visible disease and subclinical atypia. However, lesion-directed therapies are useful for lesions that are more difficult to treat or those where histologic diagnosis is required. Patients with extensive field cancerization benefit from a combination of field-directed and lesion-directed treatments. Part II of this continuing medical education review provides a framework to guide evidence-based decision making for field cancerization treatment.