Ligand efficiency indices as a navigation tool in the transthyretin protein chemico-biological space to find new amyloidogenic inhibitors

a Drug Discovery Platform (PDD), Parc Cientific de Barcelona, Barcelona, Spain b Unit of Glycoconjugate Chemistry, Institut de Quimica Avancada de Catalunya, I.Q.A.C.-C.S.I.C., Barcelona, Spain c Laboratory of Biochemistry, Institut Quimic de Sarria, Universitat Ramon Llull, Barcelona, Spain d Computer-Assisted Drug Design Laboratory, Research Group on Biomedical Informatics (GRIB) IMIM-Universitat Pompeu Fabra, Barcelona, Spain e Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 So. Ashland St, MBRB Building, Room 3020; (M/C870), Chicago, IL 60607-7173, USA