Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation

Purpose High-affinity receptor I (FceRI) on mast cells and basophils plays a key role in the immunoglobulin E (IgE)-mediated type I hypersensitivity mediated by allergen cross-linking of the specific IgE-FceRI complex. Thus, prevention of IgE binding to FceRI on these cells is an effective therapy for allergic disease. We have developed a strategy to disrupt IgE binding to FceRI using an antibody targeting FceRIα.