Randomised clinical trial: once- vs. twice-daily prolonged-release mesalazine for active ulcerative colitis.
2013
When combined with
mesalazine
enema, prolonged-release
mesalazineonce-daily 4 g is as effective and well tolerated as 2 g twice-daily for inducing remission in patients with mild-to-moderately active
ulcerative colitis(Clinicaltrials.gov: NCT00737789).
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