Synthesis of N,N′-Disubstituted 3-Aminobenzo[c] and [d]Azepin-2-ones as Potent and Specific Farnesyl Transferase Inhibitors.

A structure-activity study was performed by synthesis on N,N'-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities.