First report of an Asian family with hemoglobin Evans [α2 62 (E11) Val → Met]

HemoglobinEvans is an unstable variant caused by a single nucleotide mutation that produces a valine-to-methionine substitution at residue 62 of the α- globinchain. It has not been reported in the Asian population and only three cases have been reported worldwide. We diagnosed a Japanese boy with chronic hemolytic anemiawith hemoglobinEvans after genetic testing. This is the first familial case of hemoglobinEvans in an Asian population.