Indole derivatives hsp90 inhibitors, compositions containing them and use of them for the treatment of cancer

Their use as medicaments for the treatment of cancer. And methods for their preparation and intermediates for their synthesis. CLAIMS 1. Products of formula (1) wherein: R2 and R3 identical or different represent H, CH3, CH2CH3, CF3; Het represents a partially unsaturated aromatic heterocycle or - dihydro type or tetrahydro - mono or bicyclic 5 to 11 membered heterocycle comprising 1 to 4 heteroatoms selected from N, O or S, optionally substituted with one or more radicals R 1 or identical or different, such R'1 as described below; R is selected from the group consisting of residues of formulas group (2); with R1 and / or R'1, identical or different, selected from the group consisting of H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalkoxy, alkylthio, free or esterified carboxy by an alkyl, carboxamide, CO-NH ( alkyl), CON ( alkyl) 2, NH-CO- alkyl, sulfonamide, NH-SO2- alkyl, S (O) 2-NH- alkyl, S (O2) -N ( alkyl) 2, wherein all alkyl, alkoxy and alkylthio themselves optionally substituted by one or more identical or different radicals chosen (s) from halogen, hydroxy, alkoxy, amino, alkylamino and dialkylamino; W1, W2, W3 independently represent CH or N; X represents an oxygen atom or sulfur or NR4, C (O), S (O) or S (O) 2 radical; V represents a hydrogen atom or a halogen atom or an -O-R4 radical or a radical -NH-R4 wherein: R4 represents a hydrogen atom or a radical C1-6 alkyl, C3-8 cycloalkyl or heterocycloalkyl C3 -10, mono- or bicyclic; these radicals being alkyl, cycloalkyl and heterocycloalkyl optionally substituted with one or more identical or different radicals chosen (s) from the radicals: -O-PO3H2; -O-PO3Na2; -O-SO3H2; -O-SO3Na2; -O-CH2-PO3H2; -O-CH 2 PO3Na2; -O-CO-alanine; -O-CO-glycine; -O-CO-serine; -O-CO-lysine -O-CO-arginine; -O-CO-glycine-lysine; -O-CO-alanine-lysine; halogeno; hydroxy; mercapto; Not me; carboxamide (CONH2); carboxy; heterocycloalkyl; cycloalkyl; heteroaryl; carboxy esterified by an alkylradical; -CO-NH ( alkyl); -O-CO- alkyl; -NH-CO- alkyl; I rent; alkoxy; alkylthio; alkylamino; dialkylamino; in all these radicals last, the radicals being alkyl, alkoxy and alkylthio themselves optionally substituted by one or more identical or different selected from hydroxy, mercapto, amino, alkylamino, dialkylamino, CO2- alkyl, NHCO 2- alkyland heterocycloalkyl radicals; in all these radicals, the cycloalkyl radicals being, heterocycloalkyl and heteroaryl themselves optionally substituted with one or more identical or different radicals chosen (s) from the hydroxy, alkyl, alkoxy, CH2OH; amino, alkylamino, dialkylamino, CO2- alkylor NHCO 2 - alkyl; said products of formula (1) being in all possible tautomeric forms and possible isomeric, racemic, enantiomeric and diastereoisomeric, and the addition salts with mineral and organic acids or with mineral and organic bases of the products of formula (1), and prodrugs of formula (1). Claim 14: As industrial products, the synthesis intermediates of formulas (3), (4), (5) and (6) in which Het, R, R4, W1 and W2 substituents have the meanings given in any one of claims 1 to 6 and z, R2 and R3 have the meanings indicated above.