Neurodegeneration in Hepatic and Neurologic Wilson Disease

Clinical presentation of Wilson disease (WD) includes hepatic and neurologic manifestations. This study compares subcortical brain regions by magnetic resonance imaging (MRI) in WD patients with and without neurological symptoms. Distinct atrophy affecting the basal ganglia, accumbens and hippocampus were present in neurological WD. Cerebellar atrophy was observed in hepatic WD without neurological symptoms.