Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive DeclineNovelty and Significance
2014
Although an association between high
blood pressureand cognitive
declinehas been reported, no studies have investigated the association between home
blood pressureand cognitive
decline. Home
blood pressuremeasurements can also provide day-to-day
blood pressurevariability calculated as the within-participant SD. The objectives of this prospective study were to clarify whether home
blood pressurehas a stronger
predictive powerfor cognitive
declinethan conventional
blood pressureand to compare the
predictive powerof the averaged home
blood pressurewith day-to-day home
blood pressurevariability for cognitive
decline. Of 485 participants (mean age, 63 years) who did not have cognitive
decline(defined as
Mini-Mental State Examinationscore, <24) initially, 46 developed cognitive
declineafter a median follow-up of 7.8 years. Each 1-SD increase in the home
systolic
blood pressurevalue showed a significant association with cognitive
decline(
odds ratio, 1.48; P =0.03). However, conventional
systolic
blood pressurewas not significantly associated with cognitive
decline(
odds ratio, 1.24; P =0.2). The day-to-day variability in
systolic
blood pressurewas significantly associated with cognitive
declineafter including home
systolic
blood pressurein the same model (
odds ratio, 1.51; P =0.02), whereas the
odds ratioof home
systolic
blood pressureremained positive, but it was not significant. Home
blood pressuremeasurements can be useful for predicting future cognitive
declinebecause they can provide information not only on
blood pressurevalues but also on day-to-day
blood pressurevariability. # Novelty and Significance {#article-title-31}
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