Metabolomic profiling of aqueous humor in glaucoma points to taurine and spermine deficiency: findings from the Eye-D study
2019
We compared the
metabolomicprofile of aqueous humor from patients with primary open-angle glaucoma (POAG; n = 26) with that of a group of age- and sex-matched non-POAG controls (n = 26), all participants undergoing
cataract surgery. Supervised paired partial least squares discriminant analysis showed good predictive performance for test sets with a median area under the
receiver operating characteristicof 0.89 and a p-value of 0.0087. Twenty-three metabolites allowed discrimination between the two groups.
Univariate analysisafter the Benjamini-Hochberg correction showed significant differences for 13 of these metabolites. The POAG
metabolomicsignature indicated reduced concentrations of
taurineand
spermine, and increased concentrations of creatinine,
carnitine, three short-chain acylcarnitines, 7 amino acids (glutamine, glycine, alanine, leucine,
isoleucine, hydroxyl-proline, and acetyl-
ornithine), 7 phosphatidylcholines, one
lysophosphatidylcholine, and one
sphingomyelin. This suggests an alteration...
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