I CANNOT SMILE, DOCTOR
2012
A 24-year-old lady presented with first unilateral
facial weaknessand rapidly progressed over a few days to severe facial
diplegia, with difficulty walking and sensory disturbance in her extremities. Examination revealed bilateral lower-motor
facial nerve palsieswith no opthalmolplegia, proximal limb
girdleweakness with diminished reflexes causing impaired mobilisation, and glove-and-stocking
sensory loss. Investigations for an acute
polyneuropathysyndrome showed normal blood results, including for vasculitic and infective causes. Contrast MRI demonstrated enhancement of
cranial nerves V, VII and VIII bilaterally, and of the
cauda equina. CSF protein was elevated at 1.79 g/l. Neurophysiology showed a demyelinating process in keeping with
Guillain-Barre syndrome(GBS). A 5-day course of intravenous immunoglobulin was given, with good treatment effect allowing independent mobilisation, but the facial palsies improved only marginally and were treated supportively. Nerve enhancement in either
cranial nervesor
spinal nerveson contrast MRI in GBS is well known, more so in children. The adult-case literature reports patients with either cranial or
spinal nerveinvolvement in the clinical presentation, but changes in both sets of nerves on MRI, or vice versa. Our patient is unique for having both significant cranial and spinal involvement in both her clinical picture as well as her MRI.
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