Etelcalcetide: injectable calcimimetic for the treatment of secondary hyperparathyroidism in hemodialysis-dependent patients.
2017
Chronic kidney disease is associated with mineral and bone disorders that are now considered as a syndrome. One of the major complications of this syndrome is
secondary hyperparathyroidism(SHPT). SHPT increases bone turnover and the risk of fracture. SHPT is also associated with cardiovascular calcification and high mortality risk. The classical medical therapies of SHPT lack long-term efficacy and have undesirable effects on serum calcium and phosphate levels. Surgical
parathyroidectomyis a radical therapeutic solution potentially exposing patients to a permanent state of hypoparathyroidism among other complications. Oral
cinacalcetrevolutionized the treatment of SHPT because of its great efficacy; however, more than one-third of patients do not respond appropriately to
cinacalcet, mostly because of intolerance and lack of compliance. Intravenous
etelcalcetideimproves medical adherence and reduces pill burden. It is 10-15% superior than
cinacalcetin controlling
parathyroid hormone, but also leads to more frequent episodes of hypocalcemia.
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