Renal fibrosis: Insight from proteomics in animal models and human disease
2011
Chronic kidney disease (CKD) is the end-point of a number of renal and
systemic diseases. The high incidence and financial burden of CKD makes it imperative to diagnose CKD at early stages when therapeutic interventions are far more effective. A key component of CKD is the development of renal
fibrosis. Renal
fibrosisis a complex process, associated with many cell types and pathways, resulting in structural and functional alterations. Identification of specific biomarkers of renal
fibrosismay thus not only help us to understand the pathophysiological mechanisms involved in this process, but also improve diagnosis in the clinic. In this review, the existing literature on proteomic approaches to study renal
fibrosisis presented and evaluated. The importance of using animal models along with patient material is discussed and future directions, considered key to this field, are proposed.
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