Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

Satoru Noji,Yoshinori Hara,Tomoya Miura,Hiroshi Yamanaka,Katsuya Maeda,Akimi Hori,Hiroshi Yamamoto,Shingo Obika,Masafumi Inoue,Yasunori Hase,Takuya Orita,Satoki Doi,Tsuyoshi Adachi,Atsuo Tanimoto,Chika Oki,Yukari Kimoto,Yoshihiro Ogawa,Tamotsu Negoro,Hiromasa Hashimoto,Makoto Shiozaki

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

2020

Dermatologic disorders such as atopic dermatitis arise from genetic and environmental causes, and are complex and multi-factorial in nature. Among possible risk factors, aberrant immunological reac...

Keywords:

Biochemistry
Cancer research
Janus kinase inhibitor
Dermatologic disorders
Scaffold
Chemistry
Atopic dermatitis

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