Response to Comment on Braffett et al. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2019;42:657–664

Snaith et al. (1) suggest that the relationship between insulindose and adverse cardiometabolic profile might be mediated by insulin resistanceand cite data linkingclamp-derived measurement of insulin resistanceand coronary artery calcification (2). We do not have any direct assessment of insulin resistancein the Diabetes Controland Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study; however, the association among weight gain, insulin resistance, and adverse …