A review of methods for subtyping Yersinia pestis: From phenotypes to whole genome sequencing
2016
Numerous subtyping methods have been applied to
Yersinia pestiswith varying success. Here, we review the various subtyping methods that have been applied to Y. pestis and their capacity for answering questions regarding the
population genetics,
phylogeography, and
molecular epidemiologyof this important
human pathogen. Methods are evaluated in terms of expense, difficulty, transferability among laboratories, discriminatory power, usefulness for different study questions, and current applicability in light of the advent of
whole genome sequencing.
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