Reliability criteria for analytical methods [Biomonitoring Methods, 2010]

Published in the series Biomonitoring Methods, Vol. 12 (2010) The article contains sections titled: Introduction Pre-analytical phase Prevention of external contamination during sample collection Sampling time Sampling material Storage and transport of samples Sample documentation Stability of the chemicals, solutions and calibration standards used Selectivity Detection, identification and quantification limits Visual estimation Determination of the signal/background noise ratio Blank value procedure according to DIN 32 645 Calibration curve procedure according to DIN 32 645 Standard deviation procedure Example Calibration Selection of the calibration points One-point calibration Matrix effects Use of internal standards Linearity of the calibration function Example Precision Example Accuracy Reference material (CRM) Reference methods Inter-laboratory comparability investigations Spiking procedures Arithmetical determination of accuracy Factors influencing accuracy Comparability of methods Examples Measurement uncertainty Combined and extended measurement uncertainty Estimation of the measurement uncertainty Examples Quality assurance Internal quality assurance External quality assurance Summary Glossary Keywords: selectivity; detection limit; identification limit; quantification limit; calibration; precision; accuracy; measurement uncertainty; quality assurance; biological monitoring; occupational monitoring; environmental monitoring; biomonitoring; biomarker