Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma.

AbstractBRCA1-associated protein 1 ( BAP1) is a deubiquitinating enzymethat functions as a tumor suppressor gene. Double hit BAP1inactivation has been reported in a range of tumor types, including intrahepatic cholangiocarcinoma (ICC), sometimes in association with germlinemutation.We performed im