Can machine learning be useful as a screening tool for depression in primary care

Abstract Depression is a widespread disease with a high economic burden and a complex pathophysiology disease that is still not wholly clarified, not to mention it usually is associated as a risk factor for absenteeism at work and suicide. Just 50% of patients with depression are diagnosed in primary care, and only 15% receive treatment. Stigmatization, the coexistence of somatic symptoms, and the need to remember signs in the past two weeks can contribute to explaining this situation. In this context, tools that can serve as diagnostic screening are of great value, as they can reduce the number of undiagnosed patients. Besides, Artificial Intelligence (AI) has enabled several fruitful applications in medicine, particularly in psychiatry. This study aims to evaluate the performance of Machine Learning (ML) algorithms in the detection of depressive patients from the clinical, laboratory, and sociodemographic data obtained from the Brazilian National Network for Research on Cardiovascular Diseases from June 2016 to July 2018. The results obtained are promising. In one of them, Random Forests, the accuracy, sensibility, and area under the receiver operating characteristic curve were, respectively, 0.89, 0.90, and 0.87.