YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKK[epsiv]-mediated phosphorylation

Intracellular detection of viral invasion triggers activation of the transcription factor IRF3and antiviral interferon production. Fangfang Zhou and colleagues report that the transcription regulatorYAP in the host restrains this process by preventing inadvertent spontaneous dimerization of IRF3and its translocation to the nucleus.