CXCL7-induced macrophage infiltration in lung tumor is independent of CXCR2 expression: CXCL7-induced macrophage chemotaxis in LLC tumors
2015
Abstract
Chemokinesplay diverse roles in modulating the immune response during tumor development. Levels of CXC
chemokineligand 7 (
CXCL7) protein vary during tumorigenesis, and the evidence suggests that this
chemokineserves as a novel biomarker of early-stage lung cancer. We investigated the effect of
CXCL7gene expression on the infiltration of myeloid cells into the
tumor microenvironmentin
Lewis lung carcinoma(LLC). Tumors established from LLC cells overexpressing
CXCL7(
CXCL7-LLC tumors) increased the infiltration of CD206 + M2 macrophages at the early stages of tumorigenesis. This infiltration was independent of CXCR2 expression on either tumor cells or macrophages.
CXCL7-LLC tumors developed faster than control-LLC tumors (IRES-LLC tumor) did. The extent of CD4 + T cell, CD8 + T cell, and
natural killer T cellinfiltration was similar between the two tumor groups. Our findings suggest that
CXCL7attracts macrophages especially at the tumor site and may accelerate lung tumor development in the early stages.
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