Kuruyemiş Alerjisi Olan Çocuklarda Klinik Bulgular ve Doğal Seyrin Değerlendirilmesi

Objective: Tree nut allergies (TNA) are an important health problem can cause severe reactions such as anaphylaxis and the frequency of improvement with age is low. This study aims to evaluate the clinical features and tolerance development of TNAs. Material and Methods: In our study, the clinical characteristics, laboratory findings and tolerances of the patients who were followed with allergy to tree nuts between 2010-2017 in the Department of Pediatric Immunology and Allergy of Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital were evaluated. Results: A hundred and twenty eight (73.4% male) patients were included in the study with a median age of 61 (min-max:4-209) months. Of the patients, 109(85.2%) were hazelnuts, 60(46.8%) were allergic to walnuts, 47(36.7%) were allergic to pistachios, 37(28.9) were allergic to almonds, 22(17.2%) were allergic to cashew nuts.Presenting reaction was anaphylaxis in 47 (36,7%) patients. The median value of the follow-up period was 56.3 (16.3-134.2) months. Of the 128 patients, 37(29%) have overgrown all TNAs, 9 (7%) have outgrown some of TNAs and TNAs of 70(54.6%) patients persisted. Twelve patients (9.4%) couldn’t evaluated. Forty-two percent of patients with single TNA, 31.5% of patients with multi-TNA has developed tolerance within follow-up period. Conclusion: Tolerance development to TNA seems to be encouraging. Therefore, regular monitoring of these patients is important.