The relationships between sarcopenia and decreased bone mineral density in each obstructive airway disease phenotype of Korea

Background: Obstructive airway disease (OAD) and sarcopenia are related to decreased bone mineral density (BMD). The relationship between sarcopenia and BMD in each OAD phenotype is not known, especially asthma-COPD overlap syndrome (ACOS). Method: Among the research subjects of KNHANES IV and V (2008–2011), 5562 were aged ≥ 50 years, who underwent qualified spirometry and DXA. A total of 947 subjects were included in the study, of which 89 had asthma, 748 had COPD, and 110 had ACOS. Results: In the COPD and ACOS phenotype, each T-score were lower in the sarcopenia group than those in the non-sarcopenia group. The osteopenia and osteoporosis prevalence rates of the non-sarcopenia and sarcopenia groups were different (p Conclusion: Sarcopenia is closely related to decreased BMD in OAD phenotype such as COPD and ACOS with systemic inflammation. In the ACOS phenotype, individuals with sarcopenia had the highest prevalence rate and risk of osteopenia and osteoporosis than those with non-sarcopenia among all OAD phenotype