The effect of riluzole and mannitol on cerebral oedema after cryogenic injury in the mouse

Abstract A cryogenic lesion was produced under halothaneanaesthesia in the mouse by placing a cotton swabsoaked in liquid nitrogenonto the surface of the cranium. This provoked an oedematous lesion which developed within the hour after the insult and evolved over the following week. Treatment with mannitol at 3 g/kg i.v. caused a significant 22% reduction in oedema 1 h later, when administered immediately after lesion, but not when administered 23-h post lesion. Likewise riluzole(16 mg/kg, i.v.) significantly reduced oedema by 17% when administered immediately after lesion, or 13% ( P P P