Abstract 15854: Prevalence and Clinical Significance of Left Ventricular Outflow Tract Obstruction in Patients With Takotsubo Cardiomyopathy

Introduction: Takotsubo cardiomyopathy (TTC) is regarded a benign disease since left ventricular function normalizes within a short time. However, a number of complications have been observed in patients (pts) with this syndrome. This study evaluated the frequency and clinical significance of left ventricular outflow tract obstruction (LVOTO) in a large TTC registry. Methods: From 37 heart centres, 324 pts (296 f, 28 m, age 68±12) were included in a registry according to established TTC criteria. Complete data on complications were available in the last 209 registry pts, and those with and without LVOTO were compared. Results: Complications developed in 108/209 pts (52%) within 2.6±2.9 days after symptom onset; 51 of these pts (24%) experienced >1 complication. Most complications (77%) occurred within 3 days after symptom onset, however, 23% developed later (day 4 to 56). During the acute phase, LVOTO (ranging from 20-100 mm Hg) was seen in 10/209 pts (5%). LVOTO occurred within the first 2 days after hos...