Role of the functional polymorphism -163A>C of CYP1A2 gene and cigarette smoking in the development of coronary heart disease in the Tunisian population

Cytochrome P450 1A2 ( CYP1A2) enzyme plays an important role in the homeostasis of the cardiovascular system through the metabolism of endogenous molecules such as arachidonic acids which have cardioprotective effects and exogenous molecules like tobacco chemicals that have atherogenic effects. The objective of this study was to evaluate the association between the functional polymorphism CYP1A2-163A>C (rs762551) and coronary heart disease (CHD) in the Tunisian population and to determine whether the C allele confer a lower risk of CHD among smokers. We investigated a total of 400 controls and 379 coronary heart disease patients including 261 subjects with myocardial infarction (MI) and 118 with anginato validate this association. The results did not show any significant association between CYP1A2-163A>C polymorphism and CHD or MI. However, the homozygous genotype CC of the single nucleotide polymorphism (SNP) -163A>C was found to be significantly associated with angina(OR = 2.13; 95% CI: 1.203.77; p = 0.01). We also, found that smokers carrying CC genotype have an increased risk of angina(OR = 3.82; 95% CI: 1.55-9.39; p = 0.004) in comparison to those carrying AA genotype. Our findings suggests that the CC genotype of CYP1A2-163A>C polymorphism was associated with anginain the Tunisian population and this risk increased significantly among smokers with CC genotype.