Scientific Research
Shaoshun Li
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Overview
Shaoshun Li, Ph.D. Medicinal Chemistry (Kitasato University), Professor.
Shaoshun Li was born in 1954 in Yingkou, Liaoning, China. He graduated from Shenyang College of Pharmacy in 1982, obtained Ph. D. degree from Kitasato University in Japan in 1991, and had been doing post-doctorate research in Shenyang Pharmaceutical University from 1992 to 1994. He had been working as professor in shenyang Pharmaceutical University and Second Military Medical University from 1994 to 2001, and now is working in School of Pharmacy, Shanghai Jiaotong University as professor. He is also the member of Specialized Committee of Shanghai Pharmacy Society and the editor of Chinese journal of medicinal chemistry and Chinese Journal of Pharmaceuticals.
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Members
Defeng Xu, PhD. Medicinal Chemistry (Shanghai Jiao Tong University), Associate Researcher
Wen Zhou, PhD. Medicinal Chemistry (Shanghai Jiao Tong University), Assistant Researcher
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Research Field
Total synthesis and structure modification of naturally occurring compounds and their activity
Design, synthesis and the RSA of small modular compounds
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Publications & Patents
(1) Li-Ming Zhao , Tian-Pei Xie , Yu-Qin He , De-Feng Xu and Shao-Shun Li. Synthesis and antitumor activity of 6-and 2-(1-substituted-thio-4-methylpent-3-enyl)-5,8–dimethoxy naphthalene-1,4-diones, Eur J Med Chem, 2009,44:1410
(2)Jie Liu, Wen Zhou, Shaoshun Li et al. On of nur77-mediated apoptotic pathway by acetylshikonin and analogs, Cancer Research, 2008, 68(21):8871 (joint first authors).
(3) Li Ming Zhao , Tian Pei Xie , Yu Qin He, De Feng Xu , Shao Shun Li. Synthesis and antitumor activity of 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones, Chin Chem Lett, 2008, 19: 1206
(4) De-Feng Xu, Li-Ming Zhao, Zhi-Qiang Mao, and Shao-Shun Li. Regioselective phenyl anion transfer: application to the total synthesis of (±)-shikonin, Org Prep Proced Int,2008,41(1): 93
(5) Wen Zhou, De-Feng Xu, Ai-Hong Zhao, and Shao-Shun Li. A mild and efficient semi-synthesis of leucoacetates, J Indian Chem. Soc, 2008, 85(1): 1
(6) Li-Ming Zhao; De-Feng Xu; Wen Zhou; Shao-Shun Li. Concise formal synthesis of (±)-shikonin via a highly α-regioselective prenylation of 1,4,5, 8-tetramethoxynaphthalene- 2-carbaldehyde. Lett Org Chem 2008, 5: 234
(7) Ai-Hong Zhao, De-Feng Xu, Wen Zhou, Zhen Rao, and Shao-Shun Li. A convenient synthesis of 2-formyl-1,8:4,5- bis(methylenedioxy)naphthalene. J Chem Res, 2007, 11: 647
(8) De-Feng Xu, Peng-jian Guan, and Shao-Shun Li: A convenient synthesis of 2-formyl-1,4,5,8- tetramethoxynaphthalene, J Chem Res, 2006, 12: 779
(9) De Feng Xu, Xiao Juan Guo, Zhao Hui Xu, Shao Shun Li. A novel total synthesis of (±)shikonin, Chin Chem Lett, 2006, 17(7): 871.
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contact information
School of Pharmacy, Shanghai Jiao Tong University
800 Dongchuan Road, Shanghai, 200240
Office phone: +86-21-3420-4775
Lab. Phone: +86-21-3420-5935
Fax: +86-21-3420-4775
