Scientific Research
Chao Yan
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Overview
Group Leader:
Dr. Chao Yan, Professor / Ph.D. Supervisor, Pharmaceutical Analysis Lab, School of Pharmacy, Shanghai Jiao Tong University
Resume:
1981-1985, Teaching Assistant, Department of Chemistry, Inner Monglioa Normal University for Nationalities
1985-1991, Ph.D. Student, Department of Chemistry, Georgetown University, Washington D.C., USA
1991-1993, Post-doctor, Department of Analytical R&D of Sandoz Pharma Ltd, Switzerland
1993-1996, Research Associate, Stanford University, USA
1996-1999, Research Fellow, Sandia National Labs, USA
1996-2012, Chairman of Unimicro Technologies, Inc., USA.
1996-1999, Adjunct Professor in Tsinghua University
2000-2005, Research Professor, Ph.D. Supervisor and Group Leader supported by “Hundred Scholars Initiative”, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
2006-present, Professor, Group leader of Pharmaceutical Analysis lab, School of Pharmacy, Shanghai Jiao Tong University
2002-present, Chairman & CSO, Unimicro (Shanghai) Technologies, Co. Ltd.
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Members
Dr. Yan Wang, Associate Professor
Dr. Xue Gu, Lecturer
Dr. Jing Li, Postdoc
Dr. Xin Zhang, Adjunct Professor
Dr. Yongliang Zhu, Adjunct Professor
4 Ph.D. candidates, 20 Master candidates
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Research Field
R&D of capillary electrochromatography (CEC) and quantitative capillary electrophoresis (qCE) and their applications in the fields of pharmaceutical, biological and agriculture/food.
Metabolomics of cancer
Preparation, characterization and application of novel stationary phases and capillary monolithic columns in pressurized capillary electrochromatography (pCEC)
Screening of Active ingredients in traditional Chinese medicine and their pharmacokinetics
Drug quality control and analysis of complex biological samples.
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Publications & Patents
Huiping Zhang, Yan Wang, Xue Gu, Junyi Zhou, Chao Yan, Metabolomic profiling of human plasma in pancreatic cancer using pressurized capillary lectrochromatography. Eletrophoresis,2011, 32:340–347.
Juan Wei, Xue Gu, Yan Wang, Yi Wu, Chao Yan, Two-dimensional separation system by on-line hyphenation of capillary isoelectric focusing with pressurized capillary electrochromatography for peptide and protein mapping,Electrophoresis,2011,32(2),230-237.
Yi Wu, Yan Wang, Xue Gu, Lin Zhang, Chao Yan, Two-dimensional strong cation exchange liquid chromatography / reversed phase pressurized capillary electrochromatography for separation of complex samples, J. Sep. Sci., 2011, 34(9): 1027–1034.
Junyi Zhou, Lin Zhang Yan Wang, Chao Yan, HPLC-ELSD analysis of spectinomycin dihydrochloride and its impurities, J. Sep. Sci., 2011, 34 (15):1811–1819.
Mengjia Li,Junyi Zhou,Xue Gu,Yan Wang,Xiaojing Huang,Chao Yan, Quantitative capillary electrophoresis and its application in analysis of alkaloids in tea, coffee, coca cola, and theophylline tablets, J. Sep. Sci. 2009, 32:267 – 274.
Ying Zhou, Yan Wang, Ren Wang, Fei Guo, Chao Yan, Two-dimensional liquid chromatography coupled with mass spectrometry for the analysis of Lobelia chinensis Lour. Using an ESI/APCI multimode ion source. J. Sep. Sci, 2008, 31(13):2339-2518
Qi-Shu Qu, Xin-Xin Zhang, Zhen-Zhen Zhao, Xiao-Ya Hu, Chao Yan, Gold microspheres modified with octadecanethiol for capillary liquid chromatography. J. Chromatogr. A, 2008, 1198–1199, 95–100.
Guoxiang Xie, Mingming Su, Peng Li, Xue Gu, Chao Yan, Yunping Qiu, Houkai Li, Wei Jia, Analysis of urinary metabolites for metabolomic study by pressurized CEC. Electrophoresis, 2007, 28, 4459–4468.
Qishu Qu, Xiao Lu, Xiaojing Huang, Xiaoya Hu, Yukui Zhang, Chao Yan, Preparation and evaluation of C18-bonded 1-?m silica particles for pressurized capillary electrochromatography, Electrophoresis, 2006, 27, 3981-3987.
Zhen Liang, Jicheng Duan, Lihua Zhang, Weibing Zhang, Yukui Zhang, Chao Yan, Pressurized electrochromatography coupled with electrospray ionization mass spectrometry for analysis of peptides and proteins. Anal. Chem., 2004, 76: 6935-6940.
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Awards & Honors
Dr. Yan focuses mainly on the research and development of electrokinetic separation techniques, instrument and their applications. With experimental and theoretical studies, Dr. Yan has made initiate achievements and great contributions to the research and development of capillary electrochromatography (CEC). He leads the world in scientific publications on CEC with more than 180 articles (total cited number up to 1000) and has been invited to speak in numerous international conferences. He holds more than 30 patents in design and manufacturing of CEC instrument and capillary columns, contributing significantly to solving a variety of problems in chemical and biological analyses. He was the principle investigator of more than 30 research projects sponsored by the national and local governments, including National Key Technologies R & D Programs of China during the 9th and 15th Five-Year Plans Period, High-technological Industrialization Project of National Development and Reform Commission, National Natural Science Foundation of China, international cooperation projects with USA & Belgium, SME (small and medium-sized enterprises) Technology Innovation Fund of Ministry of Science and Technology, and Shanghai Scientific and Technological Projects, etc. In 2011, he successfully gained research funding of National Major Scientific Instruments Development Project.
2003, Golden prize of BCEIA
2004, Excellent achievement prize of Hundred Scholars Initiative
2005, Shanghai first-class Prize for Scientific and Technical Progress
2005, Shanghai Pujiang Program
2006, Shanghai excellent inventor prize
2007, Golden prize of BCEIA
2007, The national invention award
2007, State Council Expert for Special Allowance
2008, Shanghai outstanding entrepreneurs exploiting the invention
2008, Shanghai third -class prize for scientific and technical progress
2009, Contribution Award in scientific instruments
2009, National award for outstanding returned overseas Chinese
2011, Shanghai Innovation Award in Scientific Instrument
2012, Shanghai Innovation Award in Scientific Instrument
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contact information
Prof. Dr. Chao Yan, Pharmaceutical Analysis Lab
School of Pharmacy, Shanghai Jiao Tong University
No. 800 Dongchuan Road, Minhang District, Shanghai 200240, P.R. China
Tel (o): +86-21-3420-5673
Tel (l): +86-21-3420-5988
Fax: +86-21-3420-5908
E-mail: chaoyan@sjtu.edu.cn,chaoyan@unimicrotech.com
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More Information
Main Academic Employment:
Executive Director and Deputy General Secretary of Chinese Chromatography Society
Associate Editor in Chief of “Chinese Journal of Chromatography”
Vice Chairman of Shanghai Analysis Society
Associate Director of CaSSS, USA
Editorial Board Member of “Chinese Journal of Pharmaceuticals”
