Scientific Research
Lili Jing
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Overview
Lili Jing, Ph.D. Principle Investigator
Principle Investigator School of Pharmacy, Shanghai Jiaotong University, 2016-present
Principle Scientist Biologics Discovery, Wuxi Apptec, Shanghai, 2015-2016
Research Fellow Boston Children’s Hospital/Harvard University, 2009-2015
Ph.D. University of Pennsylvania, Cell and Molecular Biology, 2009
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Members
Haowi Jiang (Postdoc)
Abrar Ahmed (Ph.D. Student)
Prateek Srivastata (Ph.D. Student)
Dan Zhong (Ph.D. Student)
Wei Wang (Ph.D. Student)
Xiaona Wei (Ph.D. Student)
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Research Field
The lab focuses on the genesis and homeostasis of hematopoietic stem cells, and their differentiation towards immune cells.
Current projects include:
(1) Hematopoietic stem cell development and chemical and biological regulators
(2) Immune cells (myeloid lineages) differentiation, disease development and drug screen
(3) Interplay between immune system and microbiota (infection and intestinal microbiota)
(4) Zebrafish as a model for drug efficacy and toxicity study
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Publications & Patents
Publications:
1. L. Jing, O. Tamplin, M. Chen, Q Deng, S. Patterson, P. Kim, E. Durand, A. McNeil, J. Green, S. Matsuno, J. Ablain, M. Brandt, A. Huttenlocher, T. Schleiger, G. Daley, K. Ravid and L. Zon. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. Journal of Experimental Medicine, 212(5): 649-63, 2015.
2. J. Thornton, P. Du, L. Jing, L. Sjekloca, S. Lin, E. Grossi, P. Sliz, L. Zon and R. Gregory. Sequence-specific mono-uridylation of mature miRNAs by Zcchc6 and Zcchc11. Nucleic Acids Research, 42(18):11777-91, 2014.
3. X. Zhang, J. Ling, G. Barcia, L. Jing, R. Hill, B. Barry, J. Partlow, G. Mochida, T. Yu, J. Rodriguez, L. Zon, D. Söll, C. Walsh, R. Nabbout. Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy and Intractable Seizures. Am J Hum Genet, 94(4):547-58, 2014.
4. S. Boatman, F. Barrett, S. Satishchandran, L. Jing, I. Shestopalov and L. I. Zon. Assaying hematopoiesis using zebrafish. Blood Cells, Molecules, and Diseases, 51(4)271-76, 2013.
5. L.Jing, E. M. Durand, C. Ezzio, S. P. Pagliuca and L. I. Zon. In situ hybridization assay-based small molecule screening in zebrafish. Current Protocols in Chemical Biology, 4(2): 1102136, 2012.
6. O.Tamplin, R. White, L. Jing, S. Lacadie, P. Li, A. Taylor, and L.I.Zon. Chemical screens in zebrafish embryos. Wiley Interdisciplinary Reviews Developmental Biology, 1(3):459-68, 2012.
7. L.Jing and L.I. Zon. Zebrafish as a model for normal and malignant hematopoiesis. Disease Models and Mechanisms, 4(4): 433-8, 2011.
8. L. Jing, L. Gordon, E. Shtibin and M. Granato. Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development. PLOS One, 5(1): e8843, 2010.
9. L. Jing, J. Lefebvre, L. Gordon and M. Granato. Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged /MuSK receptor. Neuron, 61(5): 721-733, 2009.
10. J. Lefebvre, L. Jing, S. Becaficco, C. Frenzini-Armstrong and M. Granato. Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Proc. Natl. Acad. Sci. USA 104: 2483-2488, 2007.
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Awards & Honors
2016 Shanghai Pujiang Program
2009 Nachmias/Thinmann Thesis Prize, University of Pennsylvania
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contact information
Office: School of Pharmacy 6-310
Email: lilijing@sjtu.edu.cn
