教授/主任药师 医学博士（博士生导师）
开云网页登录 医学院附属第一人民医院临床药学科主任、上海市药物（中药）代谢产物研究重点实验室主任，开云网页登录 医学院\开云网页登录 药学院教授、博士生导师。

教育经历：
1990.9–1996.6, 中国药科大学, 药物分析, 博士
1984.9–1988.7, 第二军医大学, 药学, 学士
科研与学术工作经历：
2015.4-至今, 开云网页登录 , 医学院-上海市第一人民医院, 主任药师、教授
2002.2-2015.4, 第二军医大学, 药学院, 教授
1997.2-1999.2, 南京大学, 博士后
主要学术兼职：
国家自然科学基金二审专家，中国药师协会居家药学服务药师分会副主任委员，中国研究型医院学会药物评价专业委员会常务委员，海峡两岸医药卫生交流协会医院药学专业委员会常务委员，中国药理学会分析药理学专业委员会常务委员，中国药理学会药物代谢专业委员会委员，中国药理学会治疗药物监测研究专业委员会委员，中国医院协会临床药事管理专业委员会委员，中国药学会药学服务专业委员会委员；上海市药学会药物分析专业委员会主任委员，上海市药理学会药物代谢专业委员会副主任委员等。

1. 临床药学转化服务
2. 药物代谢组学与临床分析
3. 中药治疗化学生物学研究

1. Fei, Y., Wang, Y., Wu, S., Shen, F., & Fan, G. (2021). Evaluation of the efficacy and safety of a new formulation-lipid emulsion-based PTX injection: Pharmacokinetics, tissue distributions and anticancer effect on human gastric cancer cells in vitro. Biomed Chromatogr, 35(8), e5107. https://doi.org/10.1002/bmc.5107, 2021.
2. Fei, Y., Wu, S., Wang, Y., Shen, F., & Fan, G. (2021). A fast and high-sensitivity liquid chromatography-tandem mass spectrometry method combined with in vivo microdialysis for quantification of meropenem in rabbits with sepsis under the simultaneous infusion of total parenteral nutrition: Application to a pharmacokinetic study. Biomed Chromatogr, 35(7), e5100. https://doi.org/10.1002/bmc.5100, 2021.
3. L. Zhou, S. Wang, M. Chen, S. Huang, M. Zhang, W. Bao, A. Bao, P. Zhang, H. Guo, Z. Liu, G. Xie, J. Gao, Z. Wu, Y. Lou, G. Fan, Simultaneous and rapid determination of 12 tyrosine kinase inhibitors by LC-MS/MS in human plasma: Application to therapeutic drug monitoring in patients with non-small cell lung cancer, J Chromatogr B Analyt Technol Biomed Life Sci 1175 (2021) 122752.
4. S. Wu, X. Fan, J. Jiang, C.M. Ho, X. Ding, Y. Lou, G. Fan, Validation of a universal and highly sensitive two-dimensional liquid chromatography-tandem mass spectrometry methodology for the quantification of pyrazinamide, ethambutol, protionamide, and clofazimine in different biological matrices, J Chromatogr B Analyt Technol Biomed Life Sci 1151 (2020) 122141.
5. L.A. Lan, S.Y. Wu, X.G. Meng, J.J. Jiang, M.Y. Zheng, G.R. Fan, A simple liquid chromatography tandem mass spectrometric method for fast detection of hydrogen sulfide based on thiolysis of 7-nitro-2, 1, 3-benzoxadiazole ether, J Chromatogr A 1625 (2020) 461243.
6. X. Fan, J. Li, S. Wu, J. Jiang, J. Wang, S. Wang, Y. Lou, G. Fan, Field-amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9-hydroxyrisperidone in beagle dogs, J Sep Sci 43(17) (2020) 3555-3564.
7. H. Liao, D. Zhu, M. Bai, H. Chen, S. Yan, J. Yu, H. Zhu, W. Zheng, G. Fan, Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway, Cancer Cell Int 20 (2020) 480.
8. Xiangguo Meng, Jingjing Jiang, Hui Pan, Shengyuan Wu, Shuowen Wang, Yuefen Lou and Guorong Fan, Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats. Frontiers in Pharmacology, 2019, 10:1-10.
9. Liai Lan, Shengyuan Wu, Yu Shidan, Jingjing Jiang, Honghong Chen, Yuefen Lou d , Guorong Fan, Fast and direct determination of catechol-3, 6-bis(methyleiminodiacetic acid) prototype in beagle dog plasma using liquid chromatography tandem mass spectrometry: A simplified and high throughput in-vivo method for the metal chelator. Journal of Chromatography A, 1596 (2019):84-95.
10. Shengyuan Wu, Liai Lan, Jingjing Jiang, Xianting Ding, Chih-Ming Ho, Yuefen Lou d, Guorong Fan, Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC–MS/MS method coupled with 96-well Format plate. Journal of Pharmaceutical and Biomedical Analysis, 168 (2019) 44–54.
11. Ji Li , Lingli Zhang, Xianliang Cheng, Lei Zhang, Baochun Shen, Chen Qing b, Guorong Fan, Determination of d-amphetamine and diphenhydramine in beagle dog plasma by a 96-well formatted liquid-liquid extraction and capillary zone electrophoresis with field-amplified sample stacking. Journal of Pharmaceutical and Biomedical Analysis, 156 (2018) 263–271.
12. Jiajing Wang , Xin Zhao , Yuqing Cao , Shuowen Wang , Tingting Zhou , Yuefen Lou , Guorong Fan, Determination of vancomycin in serum by cyclodextrin-micellar capillary electrophoresis (CD-MEKC) and application for PDAP patients. Molecules 2017, 22, 538.
13. Yang G, Zhao X, Fan G. A modification on the vector cosine algorithm of Similarity Analysis for improved discriminative capacity and its application to the quality control of Magnoliae Flos. J Chromatogr A. 2017 Oct 6;1518:34-45.
14. Li X, Wen J, Jiang J, Zhao X, Zhou T, Fan G. Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies.Molecules. 2017 Apr 26;22(5):693.
15. Jiang J, Zhao X, Li X, Wu S, Yu S, Lou Y, Fan G. High-Throughput Determination of Sodium Danshensu in Beagle Dogs by the LCMS/MS Method, Employing Liquid-Liquid Extraction Based on 96-Well Format Plates. Molecules. 2017 Apr 25;22(5):667.
16. Zhao X, Jiang J, Yang G, Huang J, Yang G, He G, Chu Z, Hang T, Fan G . Profiling and Preparation of Metabolites from Pyragrel in Human Urine by Online Solid-Phase Extraction Coupled with High Performance Liquid Chromatography Tandem Mass Spectrometry Followed by a Macroporous Resin-Based Purification Approach.Molecules. 2017 Mar 21;22(3):494.
17. Yang G, Zhao X, Wen J, Zhou T, Fan G. Simultaneous fingerprint, quantitative analysis and anti-oxidative based screening of components in Rhizoma Smilacis Glabrae using liquid chromatography coupled with Charged Aerosol and Coulometric array Detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 1; 1049-1050:41-50.
18. Yang N, Goonatilleke E, Park D, Song T, Fan G. Lebrilla CB.Quantitation of Site-Specific Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs. Anal Chem. 2016 Jul 19; 88(14): 7091-100.
19. Fangyuan Gao, Zihua Xua, Weizhong Wang, Guocai Lu, Yvan Vander Heyden, TingtingZhou, GuorongFan. A comprehensive strategy using chromatographic profiles combined with chemometric methods: Application to quality control of Polygonum cuspidatum, Sieb. et Zucc. Journal of Chromatography A, 2016, 1466:67-75.
20. Zhu Y, Wen J, Cao Y, et al. Identification of 3',4'-DimethoxyFlavonol-3-β-d-Glucopyranoside Metabolites in Rats by Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry.[J]. Molecules, 2016, 21(4).
21. Fangyuan Gao, Tingting Zhou, Yongsheng Hu, Liai Lan, Yvan Vander Heyden, Jacques Crommen, Guocai Lu, Guorong Fan. Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process. Ind Crop Prod. 2016, 80:59-69.
22. Yuqing Cao, Jun Wen, Tingting Zhou, Guorong Fan. On-Line Organic Solvent Field Enhanced Sample Injection in Capillary Zone Electrophoresis for Analysis of Quetiapine in Beagle Dog Plasma. Molecules. 2016, 21:121-130.
23. Zhao Chen, Xiaoli Bi, Ji Li, Yuanjun Tang, Guorong Fan, Dongmei Sun. Application and optimization of organic–inorganic hybrid monolithic capillary electrochromatography for in vivo cefdinir determination with microdialysis. J Sep Sci. 2016, 39:440-449.

主持临床药学获2016年上海市卫计委重要薄弱学科和2019年上海市卫健委腾飞计划-展两翼重点学科。主持完成包括 “十一五”重大新药创制专项“综合性新药研究开发技术大平台—临床前药物代谢动力学技术平台”、“十二五”“军队特需药品药物分析与质量控制技术平台”建设和美国比尔及梅林达•盖茨基金、科技部“重大新药创制”专项、科技部863项目、科技部国际合作项目、国家自然科学基金项目以及中药现代化研究与创新药物代谢与动力学研究项目等50余项。
目前已主持完成新药研发包括药物制剂生物利用度评价、临床药代动力学研究、临床前药物代谢与动力学分析等80余项；获新药证书10余项：化学一类新药阿德福韦酯获得了国家新药证书，化学一类新药艾迪康唑乳剂、吡拉格雷钠注射液、注射用吗利福肽、注射用奥美克松钠、注射用头孢他美钠、赛拉瑞韦钾片和中药一类新药虎杖苷注射液、丹参素钠注射液取得了新药临床研究批文。研究成果获国家发明专利10余项。以第一作者或通讯作者在J Proteome Res、Toxicology、Anal Chim Acta、Anal Bioanal Chem、Talanta、J Chromatogr A、J Chromatogr B、J Pharm Biomed Anal等国际杂志发表SCI论文130余篇，主编、副主编药学教材及学术著作10余部，培养博士与硕士研究生60余名。