Role of neuronal ADAM17 in development of neurogenic hypertension

徐佳曦 博士
Department of Pharmacology and Experimental Therapeutics,
Health Sciences Center-New Orleans, Louisiana State University

时间：2019年9月27日（周五）10:00-11:00
地点：药学院5-412会议室
摘要：Chronic activation of brain renin-angiotensin system (RAS) contributes to the development of hypertension by altering autonomic balance. Beyond the essential role of Angiotensin II type 1 receptors, A Disintegrin And Metalloprotease 17 (ADAM17) is also found to promote brain RAS over-activation. ADAM17 is robustly expressed in various cell types within central nervous system. This presentation will report our recently updated knowledge regarding to the role of neuronal ADAM17 in development of hypertension, and how it is regulated by RAS during salt-sensitive hypertension.
报告人介绍：2008年毕业于中国药科大学药学专业，获学士学位；2014年毕业于河北医科大学药理学专业，获博士学位，师从国内离子通道研究权威张海林教授；2015年1月赴美国进行博士后进修，师从神经心血管研究专家Eric Lazartigues教授；2015年7月获美国心脏学会Postdoctoral Fellowship 项目资助； 2019 年 4 月获美国心脏学会 Career Development Award项目资助。研究兴趣包括细胞膜磷脂PIP2及其相关调节信号通路、解整联蛋白和金属蛋白酶ADAM17及其调节信号通路、以及神经元外泌体 （neuron-deprived exosomes）。发表SCI论文共14篇，最高影响因子15.2；获得国内外学术奖励9次。